PREPARATION OF 4-(4-FLUOROPHENYL)-N-ALKYLNIPECOTINATE ESTERS, 4-(4-FLUOROPHENYL)-N-ARYLNIPECOTINATE ESTERS AND 4-(4-FLUOROPHENYL)-N-ARALKYLNIPECOTINATE ESTERS

摘要

A process for the industrial scale manufacture of 4-(4-fluorophenyl)-N-alkylnipecotinate esters by the addition of 4-fluorophenylmagnesium halide intetrahydrofuran to 3,4-unsaturated-3-piperidine esters.