PREDICTING NEGATIVE SYMPTOM IMPROVEMENT DURING CLOZAPINE TREATMENT

摘要

A method for predicting a negative symptom change in a subject during drugtherapy isprovided. The method comprises isolating genomic DNA from a sample of thesubject,and genotyping a T5988C marker of GRIN2B gene. A GRIN2B 5988 T/T genotype ispredictive of a negative symptom improvement in the subject in response todrug therapy.The drug therapy may be clozapine therapy. Also provided is a method ofidentifying apolymorphism in a nucleotide sequence of interest that is predictive ofresponse to drugtherapy comprising the steps of assessing negative symptom improvement in apluralityof subjects during the course of drug therapy, isolating a sample comprisingDNA fromeach subject, genotyping one or more nucleotide sequences of interest in theDNA of eachsubject to identify one or more polymorphisms that exist in the one or morenucleotidesequences of interest, wherein correlation of a significant improvement ofnegativesymptoms with one or more polymorphisms is predictive of response to drugtherapy.