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URINARY PROTEOMIC BIOMARKER PATTERNS IN PREECLAMPSIA

机译:中小学生泌尿蛋白质组学生物标志物模式

摘要

The invention relates, in part, to methods of using proteomic biomarkers to diagnose preeclampsia. In some aspects the invention, in part, relates to the detection of serpina-1 polypeptide and/or albumin polypeptide in samples from pregnant subjects. Samples from subjects maybe compared to control samples to diagnose preeclampsia and/or to determine the onset, progression, or regression of preeclampsia in a subject. The invention also relates, in part, to screening methods to identify agents that can be used to treat preeclampsia and to determine the efficacy of a preeclampsia treatment. The invention, in part, also includes kits that are useful to diagnose and assess preeclampsia in a subject.
机译:本发明部分地涉及使用蛋白质组生物标志物来诊断先兆子痫的方法。在一些方面,本发明部分涉及检测来自怀孕受试者的样品中的serpina-1多肽和/或白蛋白多肽。可以将来自受试者的样品与对照样品进行比较以诊断先兆子痫和/或确定受试者先兆子痫的发作,进展或消退。本发明还部分地涉及用于鉴定可用于治疗先兆子痫并确定先兆子痫治疗功效的药物的筛选方法。本发明部分地还包括可用于诊断和评估受试者的先兆子痫的试剂盒。

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