LOW-GLUCOSE-INDUCIBLE OR LOW-GLUCOSE-AND-HYPOXIA-INDUCIBLE GENES, PROTEINS, AND USES THEREOF

摘要

The present inventors discovered that the low-glucose environment surrounding a tumor also contributes to its resistance to chemotherapy, and inhibition of low-glucose-induced gene leads to the apoptosis of tumor cells. The present inventors also discovered that inhibition of genes induced in the low-glucose micoroenviroment or low-glucose-and-hypoxia micoroenviroment may cause apoptosis to tumor cells. With this discovery, the inventors provide microarrays for detection of a low -glucose micoroenviroment or a low-glucose-and-hypoxia micoroenviroment, a method of treatment of solid tumors and a method of detections of solid tumors.