2,2'-ALKYISUBSTITUTED-3,4-DEHYDRO-6-ALKYLAMINO BENZOPYRAN DERIVATIVES AS PROTECTION AGENTS FOR CEREBRAL CELL DEATH

摘要

A 2,2'-alkylsubstitued-3,4-dehydro-6-alkylamino benzopyran derivative is provided to secure the activity of controlling neuronal death by controlling the activity of a glutamate receptor, thereby being useful as a prophylactic and therapeutic agent of stroke, epilepsy, amyotrophic lateral sclerosis, Parkinson's diseases, Huntington's disease and Alzheimer's disease. A pharmaceutical composition comprises a 2,2'-double substituted-7,8-double substituted-6-alkylamino benzopyran derivative represented by the formula(1) or a pharmaceutically acceptable salt thereof. In the formula(1), R^1 is C1-10 alkyl, benzyl, or substituted benzyl, phenethyl, 2-pyrimidylmethyl, thiophene, 2-methylthiophenemethyl, 5-methyl-2-thiophenemethyl, 3-thiophenemethyl, indolylmethyl, benzo dioxiranylmethyl, naphthalenylmethyl, or furanylmethyl, each R^2 and R^3 is H, C1-6 alkyl, halogen, or phenyl and substituted phenyl, R^4 is C1-10 alkyl, phenyl or substituted phenyl, or a hetero-cyclic group selected from the group consisting of thiophene and furan(wherein the benzyl, phenyl or the heterocyclic group is able to be substituted by 1-4 substituents selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, nitro, cyano and C1-6 alkoxy), and n is an integer from 1 to 5.