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IMIDAZOPYRIDINE DERIVATIVES FOR USING IN THERAPY AS MEDICINAL AGENT INHIBITING PROTON PUMP AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING
IMIDAZOPYRIDINE DERIVATIVES FOR USING IN THERAPY AS MEDICINAL AGENT INHIBITING PROTON PUMP AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING
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机译:咪唑并吡啶衍生物在治疗中用作抑制质子泵及其中间体的药物
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FIELD: organic chemistry, medicine, pharmacy.;SUBSTANCE: invention relates to imidazopyridine derivatives of the formula (I): that are inhibitors of proton pump. Invention describes compound of the formula (I) or its pharmaceutical acceptable salt wherein Het represents a 5-6-membered aromatic heterocyclic group comprising at least one atom of oxygen or sulfur and substituted with group R3 and group R4 at ortho-positions; R1 represents hydrogen atom (H), -CH3 or -CH2OH; R2 represents -CH3 or -CH2CH3; R3 and R4 are chosen independently from the following group: H, (C1-C6)-alkyl, hydroxylated (C1-C6)-alkyl; R5 and R6 are chosen independently from hydrogen atom, (C1-C6)-alkyl, hydroxylated (C1-C6)-alkyl, (C1-C6)-alkoxy-(C1-C6)-alkyl, hydroxylated (C1-C6)-alkoxy-(C1-C)-alkyl, either R5 and R6 can form morpholine or hydroxylated pyrrolidine in common with nitrogen atom to which they are bound; X represents -NH; R10 represents -CH2-. Also, invention describes intermediate compounds used for their synthesis. Invention provides preparing novel compounds possessing useful biological properties.;EFFECT: valuable medicinal properties of compounds and medicinal agents.;2 cl, 1 tbl, 23 ex
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