首页>
外国专利>
Use of C-glycoside compound to fight against weakening of natural defense of skin, strengthen natural defense of skin, stimulate epidermis immune defense and/or prevent-treat cutaneous autoimmune disease and atopic disorders
Use of C-glycoside compound to fight against weakening of natural defense of skin, strengthen natural defense of skin, stimulate epidermis immune defense and/or prevent-treat cutaneous autoimmune disease and atopic disorders
Use of C-glycoside compound (I) to fight against weakening of natural defense of skin due to chronological or photoinduced aging, strengthen natural defense of skin, stimulate epidermis immune defense and/or prevent and/or treat cutaneous autoimmune disease and atopic disorders. Use of C-glycoside compound of formula (I) to fight against weakening of natural defense of skin due to chronological or photoinduced aging, strengthen natural defense of skin, stimulate epidermis immune defense and/or prevent and/or treat cutaneous autoimmune disease and atopic disorders. X : -CO- (preferred), -CH(NR 1R 2)-, -CHR1- or -C(=CHR2)-; R : 1-18C alkyl, 1-18C perfluoroalkyl, 1-18C hydrofluoroalkyl, 1-18C cycloalkyl, 1-18C (cyclo)perfluoroalkyl, 1-18C (cyclo)hydrofluoroalkyl (all optionally interrupted by O, S, N or Si, and optionally substituted by OR1a, -S 1R1b, -NR1cR2a, -COOR2b, -CONHR2c, CN, halo, perfluoroalkyl, hydrofluoroalkyl and/or cycloalkyl, aryl or optionally substituted heterocyclyl) or phenyl, preferably CH 3 or phenyl; R1, R 1, R 2R, H or OH; R2 : H, R, OH or T; T : 1-20C alkyl, 1-20C hydroxyl perfluoroalkyl and/or 1-20C hydrofluoroalkyl; R1a-R1c, R2a-R2c : H or T; and S 1L-fucose. Provided that R 1 and R 2 are not simultaneously hydroxyl groups; and R1c and R2a are not simultaneously hydroxyl groups. Independent claims are also included for the following: (1) a process to remove signs of fatigue skin by stimulating regeneration of the epidermal cell comprising applying (I) on the face; and (2) a process for human keratinous fibers and/or skin e.g. scalp to stimulate the growth of human keratinous fibers and/or restrict hair-fall comprising applying the composition, leaving the composition to contact with the fibers and/or the skin, and optionally rinsing the fibers and/ or the skin. [Image] ACTIVITY : Dermatological; Antipsoriatic; Anti-inflammatory; Immunosuppressive; Endocrine-Gen; Antiallergic; Antiinflammatory. MECHANISM OF ACTION : Lymphocyte T stimulator. The ability of 1-(C-~b-D-galactopyranosyl)-propane-2-one to stimulate lymphocyte T cell was tested. The result showed that the percentage of stimulation was 136% at 1 mM and 129% at 10 mM.
展开▼