首页> 外国专利> Use of C-glycoside compound to fight against weakening of natural defense of skin, strengthen natural defense of skin, stimulate epidermis immune defense and/or prevent-treat cutaneous autoimmune disease and atopic disorders

Use of C-glycoside compound to fight against weakening of natural defense of skin, strengthen natural defense of skin, stimulate epidermis immune defense and/or prevent-treat cutaneous autoimmune disease and atopic disorders

机译:C-糖苷类化合物用于抵抗削弱皮肤的自然防御能力,增强皮肤的自然防御能力,刺激表皮免疫防御能力和/或预防皮肤自身免疫性疾病和特应性疾病

摘要

Use of C-glycoside compound (I) to fight against weakening of natural defense of skin due to chronological or photoinduced aging, strengthen natural defense of skin, stimulate epidermis immune defense and/or prevent and/or treat cutaneous autoimmune disease and atopic disorders. Use of C-glycoside compound of formula (I) to fight against weakening of natural defense of skin due to chronological or photoinduced aging, strengthen natural defense of skin, stimulate epidermis immune defense and/or prevent and/or treat cutaneous autoimmune disease and atopic disorders. X : -CO- (preferred), -CH(NR 1R 2)-, -CHR1- or -C(=CHR2)-; R : 1-18C alkyl, 1-18C perfluoroalkyl, 1-18C hydrofluoroalkyl, 1-18C cycloalkyl, 1-18C (cyclo)perfluoroalkyl, 1-18C (cyclo)hydrofluoroalkyl (all optionally interrupted by O, S, N or Si, and optionally substituted by OR1a, -S 1R1b, -NR1cR2a, -COOR2b, -CONHR2c, CN, halo, perfluoroalkyl, hydrofluoroalkyl and/or cycloalkyl, aryl or optionally substituted heterocyclyl) or phenyl, preferably CH 3 or phenyl; R1, R 1, R 2R, H or OH; R2 : H, R, OH or T; T : 1-20C alkyl, 1-20C hydroxyl perfluoroalkyl and/or 1-20C hydrofluoroalkyl; R1a-R1c, R2a-R2c : H or T; and S 1L-fucose. Provided that R 1 and R 2 are not simultaneously hydroxyl groups; and R1c and R2a are not simultaneously hydroxyl groups. Independent claims are also included for the following: (1) a process to remove signs of fatigue skin by stimulating regeneration of the epidermal cell comprising applying (I) on the face; and (2) a process for human keratinous fibers and/or skin e.g. scalp to stimulate the growth of human keratinous fibers and/or restrict hair-fall comprising applying the composition, leaving the composition to contact with the fibers and/or the skin, and optionally rinsing the fibers and/ or the skin. [Image] ACTIVITY : Dermatological; Antipsoriatic; Anti-inflammatory; Immunosuppressive; Endocrine-Gen; Antiallergic; Antiinflammatory. MECHANISM OF ACTION : Lymphocyte T stimulator. The ability of 1-(C-~b-D-galactopyranosyl)-propane-2-one to stimulate lymphocyte T cell was tested. The result showed that the percentage of stimulation was 136% at 1 mM and 129% at 10 mM.
机译:C-糖苷化合物(I)用于抵抗由于时间顺序或光致老化引起的皮肤自然防御能力减弱,增强皮肤的自然防御能力,刺激表皮免疫防御能力和/或预防和/或治疗皮肤自身免疫性疾病和特应性疾病的用途。式(I)的C-糖苷化合物用于抵抗由于时间顺序的或光诱导的衰老引起的皮肤自然防御能力的减弱,增强皮肤的自然防御能力,刺激表皮免疫防御能力和/或预防和/或治疗皮肤自身免疫性疾病和特应性的用途失调。 X:-CO-(优选),-CH(NR 1R 2)-,-CHR1-或-C(= CHR2)-; R:1-18C烷基,1-18C全氟烷基,1-18C氢氟烷基,1-18C环烷基,1-18C(环)全氟烷基,1-18C(环)氢氟烷基(均可选地被O,S,N或Si中断,并任选地被OR1a,-S 1R1b,-NR1cR2a,-COOR2b,-CONHR2c,CN,卤素,全氟烷基,氢氟烷基和/或环烷基,芳基或任选取代的杂环基取代)或苯基,优选CH 3或苯基; R 1,R 1,R 2R,H或OH; R2:H,R,OH或T; T:1-20C烷基,1-20C羟基全氟烷基和/或1-20C氢氟烷基; R1a-R1c,R2a-R2c:H或T;和S 1L-岩藻糖。假设R 1和R 2不同时为羟基; R 1c和R 2a不同时为羟基。还包括以下方面的独立权利要求:(1)通过刺激表皮细胞的再生来去除疲劳皮肤的迹象的方法,包括在脸上施加(I); (2)用于人角蛋白纤维和/或皮肤例如皮肤的方法。头皮以刺激人角蛋白纤维的生长和/或限制脱发,包括施加组合物,使组合物与纤维和/或皮肤接触,以及任选地漂洗纤维和/或皮肤。 [图像]活动:皮肤病;对牛皮癣;消炎(药;免疫抑制内分泌基因抗过敏;消炎(药。作用机理:淋巴细胞T刺激物。测试了1-(C-b-D-吡喃半乳糖基)丙烷-2-酮刺激淋巴细胞T细胞的能力。结果表明,刺激百分数在1 mM时为136%,在10 mM时为129%。

著录项

  • 公开/公告号FR2899474A1

    专利类型

  • 公开/公告日2007-10-12

    原文格式PDF

  • 申请/专利权人 LOREAL SOCIETE ANONYME;

    申请/专利号FR20060051266

  • 发明设计人 PINEAU NATHALIE;DALKO MARIA;

    申请日2006-04-07

  • 分类号A61K31/351;A61K8/60;A61P17;A61Q5;

  • 国家 FR

  • 入库时间 2022-08-21 20:26:48

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