Phenotype analysis method and genotyping of hepatitis B, which exhibit resistance to anti-viral molecules

摘要

A method of preparing HBV genomic amplification products, by using the same amplification products obtained from a patient, analyzing the genotype, phenotype, replication competent, the present invention is resistant to the antiviral agent To provide a method capable of evaluating the HBV species show. By the method of the present invention, in vitro replication capability closest is obtained as compared with in vivo replication is guaranteed, in the case of evaluating the ability to replicate and sensitivity of the agent, the effects of all mutations present in the viral genome thus ensuring that There you are take into account.