Described the invention relating to the aid of recombinant microorganism the United States government in order to high producing an organic acid, was made in response to the assistance from the United States government in (CooperativeAgreementNo.) DE-FC36-02GO12001 cooperation contract number that has been awarded by the Department of Energy. The United States Government has certain rights in this invention.

摘要

Discloses recombinant microorganisms for producing organic acids. The recombinant microorganism expresses a polypeptide having the enzymatic activity of an enzyme utilized in the pentose phosphate cycle. As the recombinant microorganism, it is possible to increase the recombinant Actinobacillus succinogenes was transformed to express the (Zwf) gene Zwischenferment. The recombinant microorganism can be useful in fermentation processes for producing organic acid such as lactic acid and succinic acid. It also disclosed a new plasmid useful for so as to generate a recombinant microorganism expressing an enzyme such as Zwf, transforming microbial.