Novel indole derivatives that alkylate specific base sequences of DNA, and alkylating agents and drugs using the same

摘要

A novel pyrrole-imidazole polyamide compound that can be synthesized in a shorter reaction step than conventional hybrid molecules, and has a highly reactive DNA alkylating ability and sequence recognition ability, and alkylates a specific base sequence of DNA, and Provided alkylating agents and drug functional molecules used. The following general formula (1), wherein R1 is a functional group that alkylates DNA, R2 is a hydrogen atom, an alkyl group or an acyl group, X is a structural unit (m is an integer of 0 to 10) , A divalent group consisting of one of the structural units, or a divalent group consisting of two or more of the structural units which may be the same or different, provided that among the structural units, the R2 side terminal Is an indole derivative represented by the following formula (wherein k may be an integer of 0 to 10).