Tumor-Homing Cells Engineered to Produce Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (Trail) by Adenoviral-Mediated Gene Transfer

摘要

The invention refers to tumor-homing cells expressing the tumor necrosis factor-related apoptosis inducing ligand (TRIAL), particularly to CD34+ and NK cells transduced with adenoviral vetors coding for TRIAL. The cells of the invention are useful for the intravenous treatment of tumors, particularly of lymphoma.