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Veto cells effective in preventing graft rejection and devoid of graft versus host potential
Veto cells effective in preventing graft rejection and devoid of graft versus host potential
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机译:veto细胞可有效防止移植排斥和缺乏移植物抗宿主潜能
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摘要
A method of transplanting a transplant derived from a donor into a recipient is disclosed. The method comprises the steps of (a) transplanting the transplant into the recipient; and (b) administering to the recipient a dose including non-alloreactive anti-third party cytotoxic T-lymphocytes (CTLs), wherein the non-alloreactive anti-third party CTLs are generated by directing T-lymphocytes of the donor against a third party antigen or antigens, the dose is substantially depleted of T-lymphocytes capable of developing into alloreactive CTLs, thereby preventing or ameliorating both graft rejection by the recipient and graft versus host disease.
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