Continuous melt spheronization apparatus and process for the production of pharmaceutical pellets

摘要

Spherically-shaped pharmaceutical pellets are produced using a novel spheronization apparatus in a continuous melt spheronization process in which an active pharmaceutical agent is blended with various excipients, fed to an extruder, cut and subsequently fed to the novel spheronizer for continuously producing uniform, spherically-shaped pellets. The pellets may be further coated so as to provide immediate or various modified release characteristics.