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Microchannel array component, microchannel array for recovering biomolecules, and method for recovering biomolecules

机译:微通道阵列组件,用于回收生物分子的微通道阵列以及回收生物分子的方法

摘要

Various types of biomolecules as the objects of recovery included in a sample solution in minute amounts are separated in accordance with their affinity for various types of probe molecules and readily recovered. A sample solution 8 including biomolecules 7 as the objects of recovery are poured into a microchannel array 6. After the biomolecules 7 are bound to probe molecules which are fixed on the wall of a microchannel in the form of spots and which have a high affinity for the biomolecules 7, a second substrate having periodic protrusions is removed from the microchannel array 6. A portion of the microchannel array 6 that includes a spot in which the probe molecules that are bound to the biomolecules 7, which are the objects of recovery for the first substrate, are fixed is cut with a sharp cutting knife, for example, thereby obtaining a piece that retains on the surface the probe molecules that are bound to the biomolecules 7.
机译:根据它们对各种探针分子的亲和力,将微量的各种生物分子作为样品溶液中所包含的回收对象进行分离,并易于回收。将包含作为回收对象的生物分子 7 的样品溶液 8 倒入微通道阵列 6 中。将生物分子 7 结合到以斑点形式固定在微通道壁上并且对生物分子 7 具有高亲和力的探针分子后,从微通道阵列 6 中去除具有周期性突起的基板。微通道阵列 6 的一部分包括一个斑点,在该斑点中,与生物分子 7 结合的探针分子是第一底物的回收对象,例如,用锋利的切割刀切割固定物,从而获得将结合到生物分子 7的探针分子保留在表面上的片。

著录项

  • 公开/公告号US2007264726A1

    专利类型

  • 公开/公告日2007-11-15

    原文格式PDF

  • 申请/专利权人 OSAMU KOGI;

    申请/专利号US20070819558

  • 发明设计人 OSAMU KOGI;

    申请日2007-06-28

  • 分类号G01N33/00;

  • 国家 US

  • 入库时间 2022-08-21 20:14:52

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