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Methods and Compositions For Specifically Targeting Human Hepatocellular Carcinoma Cells
Methods and Compositions For Specifically Targeting Human Hepatocellular Carcinoma Cells
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机译:特异性靶向人肝癌细胞的方法和组合物
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摘要
Particular aspects of the present invention provide methods and compositions for the targeting and/or treating hepatocellular carcinoma (HCC) cells to affect cancer cell growth or viability. Exemplary methods and compositions relate to cell-associated HCC proteins (e.g., SEQ ID NOS:1-8, corresponding to PGMRCI (prostaglandin receptor membrane component 1), SEMA5A (semaphorin 5A), SLC2A2 (solute carrier family member), ABCC2 (ATP-binding cassette subfamily C member 2) and HAL (histidine ammonia lyase)), and are based, at least in part, upon the discovery that specific target genes and/or gene products are up or down-regulated in diseased tissue relative to normal tissue or in tissue of patients having other ailments. Inventive compositions comprise, for example, antibodies, antisense and siRNA agents.
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机译:本发明的特定方面提供了用于靶向和/或治疗肝细胞癌细胞(HCC)以影响癌细胞生长或生存力的方法和组合物。示例性的方法和组合物涉及与细胞相关的HCC蛋白(例如,SEQ ID NO:1-8,对应于PGMRCI(前列腺素受体膜成分1),SEMA5A(信号蛋白5A),SLC2A2(溶质载体家族成员),ABCC2(ATP) -结合盒亚家族C成员2)和HAL(组氨酸氨裂合酶),并且至少部分地基于以下发现:特定靶基因和/或基因产物在患病组织中相对于正常组织被上调或下调组织或其他疾病患者的组织中。本发明的组合物包含例如抗体,反义和siRNA试剂。
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