首页>
外国专利>
A32 Monoclonal Antibody Fusion Proteins For Use As Hiv Inhibitors And Vaccines
A32 Monoclonal Antibody Fusion Proteins For Use As Hiv Inhibitors And Vaccines
展开▼
机译:用作HIV抑制剂和疫苗的A32单克隆抗体融合蛋白
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention provides a fusion protein, which comprises an antigen binding portion of an A32 human antibody, or variant thereof, and one of the following: (a) an antigen-binding portion of a second antibody or variant thereof, wherein the second antibody binds to an epitope of an envelope protein of a human immunodeficiency virus (HIV) that is exposed upon the HIV binding to a CD4 receptor, (b) an immunogenic portion of an envelope protein of a HIV, or a variant thereof, or (c) a soluble CD4 (sCD4) polypeptide capable of binding to HIV, or a or variant thereof.
展开▼