Substituted 9A-N-N'-(Benzenesulfonyl)Carbamoyl-Y-Aminopropyl and 9A-N-N'(B-Cyanoethyl)-N'-(Benzenesulfonyl)Carbamoyl-Y-AminopropylDerivatives of 9-Deoxo-9-Dihydro-9A-Aza-9A-Homoerithomycin A

摘要

The invention relates to substituted 9a-N—[N′-(benzenesulfonyl)carbamoyl-γ-aminopropyl] and 9a-N—[N′-(β-cyanoethyl)-N′-(benzenesulfonyl)carbamoyl-γ-aminopropyl] derivatives of 9-deoxo-9-dihydro-9a-aza-9a-homoerithromycin A and 5-( )-desosaminyl-9-deoxo-9-dihydro-9a-aza-9a-homoerithronolide A, novel semisynthetic macrolide antibiotics of the azalide series, of the formula (I) wherein R represents H or cladinosyl moiety, R¹ represents H or β-cyanoethyl group an R² represents II or fluoro, chloro and methyl group, and pharmaceutically acceptable salts thereof with inorganic or organic acids, to the process for the preparation of pharmaceutical compositions as well as to the use their compositions for sterilization rooms and medical instruments as well as for protection of wall and wooden coatings.