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DNA encoding T-1249 and other viral fusion inhibitor peptides useful for treating aids
DNA encoding T-1249 and other viral fusion inhibitor peptides useful for treating aids
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机译:编码可用于治疗艾滋病的T-1249和其他病毒融合抑制剂肽的DNA
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摘要
The present invention relates to enhancer peptide sequences originally derived from various retroviral envelope (gp41) protein sequences that enhance the pharmacokinetic properties of any core polypeptide to which they are linked. The invention is based on the discovery that hybrid polypeptides comprising the enhancer peptide sequences linked to a core polypeptide possess enhanced pharmacokinetic properties such as increased half life. The invention further relates to methods for enhancing the pharmacokinetic properties of any core polypeptide through linkage of the enhancer peptide sequences to the core polypeptide. The core polypeptides to be used in the practice of the invention can include any pharmacologically useful peptide that can be used, for example, as a therapeutic or prophylactic reagent.
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