low concentration photosensitizer formulation and low concentration therapy method for pdt treatment of disease

摘要

Low Concentration Photosensitizer Formulation and Low Concentration Therapy Method for PDT Treatment of Disease. A low concentration formulation for hydrophobic photosensitizers (PS) and improved method of photodynamic therapy ("PDT"). PDT treatments using the low concentration formulations described have been found to provide the most accurate, most efficient and most convenient dosages. The inventive formulation (1) has been found to reduce the time for a therapeutically effective level of photosensitizer to accumulate in diseased tissue and (2) to reduce the time to achieve a sufficient photosensitizer ratio in diseased versus healthy tissue. As a result, the formulation of the invention reduces the time interval between PS application / administration and irradiation (the drug-light or "DLI" interval) and may provide a same-day treatment option. "The inventive formulation may be used for PDT treatment regimens where photosensitizers are administered at least one preselected dose, including a low concentration PDT therapy.In particular, when the photosensitizer is meta Tetrahydroxy-Phenyl Chlorine (m-THPC), then A concentration of 0.8 mg / ml to 0.04 mg / ml in a pure propylene glycol and ethanol mixture in a 3: 2 volume ratio accumulates in diseased tissue and differentiates rapidly enough between diseased tissue and normal tissue to make administration of activation treatment possible.