isolated antibody, or fragment thereof, pharmaceutical composition, methods for preventing the binding of diffusible abeta-derived ligands to a neuron, to inhibit the formation of diffusible ligands, to block protein phosphorylation, to treat a disease prophylactically or therapeutically, to identify a therapeutic agent, detect diffusible ligands, and diagnose a disease, and, kit to detect diffusible ligands

摘要

ISOLATED ANTIBODY, OR FRAGMENT OF THE SAME, PHARMACEUTICAL COMPOSITION, METHODS TO PREVENT BINDING OF DIFFICULT LEAGERS DERIVED FROM OPEN TO A NEUREN, TO INHIBIT THE CONSTITUTION OF DIFFERENTIAL DIFFERENTIAL LEAGERS, IDENTIFY A THERAPEUTIC AGENT, TO DETECT DIFFICULT LEADERS, AND TO DIAGNOSE A DISEASE, AND KIT TO DETECT DIFFICULT LEADERS. The present invention relates to antibodies that differentially recognize multi-dimensional conformations of diffusible ligands derived from A?, Also known as ADDLs. Antibodies of the invention can distinguish between Alzheimer's disease human brain extracts and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's disease. The present antibodies also biochemize ADDLs binding to neurons, ADDLS constitution, and tau phosphorylation and are therefore useful in methods for the prevention and treatment of diseases associated with soluble β1-42 amyloid oligomers.