Stable formulation comprising an acetic acid buffer, a buffer of glutamic acid or SUCCINIC ACID buffer with a pH of 4.5 to 7At least one component comprising a Sugar or polyol, and an Antibody anti - factor receptor d

摘要

The invention provides a formulation including an acetic acid buffer, a glutamic acid buffer or a succinic acid buffer with a pH from about 4.5-7.0, at least one excipient comprising a sugar or a polyol and an effective amount of a therapeutic antibody. The buffer can include a salt of acetate, glutamate or succinate and the sugar or polyol can include glycerol, sucrose, trehalose or sorbitol. The therapeutic antibody can include a human antibody, a humanized antibody, a chimeric antibody, or a functional fragment thereof.