Compounds derived from 3 - hydroxy - 1H - pyrimidine - 4 - one or 3 - hydroxy - piran - 4 - One; Preparation procedure; Pharmaceutical Composition and use for treating neurodegenerative disease caused by PThe presence of Free iron or iron accumulation in neuronal tissues, such as Parkinson's and Alzheimer's disease.

摘要

The present invention relates to novel derivatives of deferiprone. In particular, the present invention relates to fluorinated derivatives of deferiprone or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, processes for the manufacture thereof and their use in the treatment of neurodegenerative diseases caused by the presence of free iron or iron accumulation in neural tissues and in diseases wherein excess iron must be removed or redistributed.