首页>
外国专利>
Regulation of hematopoietic stem cell differentiation using human mesenchymal stem cells
Regulation of hematopoietic stem cell differentiation using human mesenchymal stem cells
展开▼
机译:使用人间充质干细胞调节造血干细胞分化
展开▼
页面导航
摘要
著录项
相似文献
摘要
The invention relates to the induction of hematopoietic stem cells to differentiate into osteoclasts by culturing hematopoietic stem cells with human mesenchymal stem cells, and, in a preferred embodiment, using no exogenous cytokines. Differentiation of the mesenchymal stem cells into osteoblasts inhibited the differentiation of hematopoietic stem cells into osteoclasts. In addition, hematopoietic stem cells can be genetically engineered to carry genes of interest particularly for the expression of physiologically active proteins. In the presence of mesenchymal stem cells, the transduced cells carry the new genetic material and express gene products that can be used to modulate bone resorption.
展开▼