New 3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino(4,5-b)indole-1-carboxamide derivatives are peripheral benzodiazepine receptor ligands, useful e.g. for treating neurodegenerative diseases

摘要

3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino(4,5-b)indole-1-carboxamide derivatives (I) are new. 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino(4,5-b)indole-1-carboxamide derivatives of formula (I) and their acid addition salts, solvates and hydrates are new. X = H or halo; R1 = H or 1-4C alkyl; R2, R3 = H or 1-4C alkyl; or NR2R3 = pyrrolidinyl, piperidinyl, morpholinyl or 4-alkylpiperazinyl; and Het = pyridyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl, all optionally substituted by halo, 1-4C alkyl and 1-4C alkoxy. Independent claims are also included for: (1) preparation of (I); and (2) compounds of formula (II)-(V). R = H or R''; and R', R'' = 1-4C alkyl.