QUINOLIN-, ISOQUINOLIN- AND QUINAZOLIN-OXIALQUILAMIDAS AND ITS USE AS FUNGICIDES.

摘要

A compound of the general formula (1): (See formula) wherein one of X and Y is N or N-oxide and the other is CR or both of X and Y are N; Z is H, halo, C1-6 alkyl optionally substituted with halo or C1-4 alkoxy, C3-6 cycloalkyl optionally substituted with halo or C1-4 alkoxy, C2-4 alkenyl optionally substituted with halo, C2-4 alkynyl optionally halo substituted, C1-6 alkoxy optionally substituted with halo or C1-4 alkoxy, C2-4 alkenyloxy optionally substituted with halo, C2-4 alkynyloxy optionally substituted with halo, cyano, nitro, C1-4 alkoxycarbonyl, -OSO2R? , S (O) nR¿, -COR¿, -CONR¿R¿¿, -CR¿ = NOR¿, NR¿R¿¿, NRCOR¿, NR¿CO2R¿ where n is 0, 1 or 2 , R¿ is C1-6 alkyl optionally substituted with halo and R¿ and R¿ are independently H or C1-6 alkyl, or in the case of -CONR¿R¿ can be attached forming a 5 or 6-membered ring containing a single nitrogen atom, saturated carbon atoms and optionally a single oxygen atom; R is H, halo, C 1-8 alkyl, C 3-6 cycloalkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 1-8 alkoxy, C 1-8 alkylthio, nitro, amino, mono- or di- (C 1-6 alkyl -amino), mono- or di-C2-8-amino-amino, mono- or di-C2-6-amino alkynyl, formylamino, C1-4 alkyl (formyl) amino, C1-4 alkylcarbonylamino, C1-4 alkoxy -carbonylamino, C 1-4 alkyl (C 1-4 alkylcarbonyl) amino, cyano, formyl, C 1-4 alkylcarbonyl, C 1-4 alkoxycarbonyl, aminocarbonyl, mono- or di-C 1-4 alkylcarbonyl, carboxy, C1-4 alkylcarbonyloxy, aryl C1-4 alkylcarbonyloxy, C1-4 alkyl sulfinyl, C1-4 alkyl sulfonyl or C1-4 alkyl sulfonyloxy; R1 is C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, in which the alkyl, alkynyl and alkenyl groups are optionally substituted on their terminal carbon atom with one, two or three halogen atoms, with a cyano group , with a C1-4-alkyl-carbonyl group, with a C1-4-carbonyl alkoxy group or with a hydroxy group, or R1 is alkoxyalkyl, alkylthioalkyl, alkylsulfinylalkyl or alkylsulfonyl alkyl in which the total number of carbon atoms is 2 or 3 , or R1 is a C1-4 straight chain alkoxy group; R 2 is H, C 1-4 alkyl, C 1-4 alkoxy or benzyloxymethyl in which the phenyl ring of the benzyl moiety is optionally substituted with C 1-4 alkoxy; R3 and R4 are independently H, C1-3 alkyl, C2-3 alkenyl or C2-3 alkynyl, with the proviso that both are not H and that when both are different from H, the combined total of carbon atoms does not exceed 4, or R3 and R4 together with the carbon atom to which they are attached form a 3 or 4 membered carbocyclic ring that optionally contains an O, S or N atom and optionally substituted with halo or C1-4 alkyl; and R5 is H, C1-4 alkyl or C3-6 cycloalkyl, in which the alkyl or cycloalkyl group is optionally substituted with halo, hydroxy, C1-6 alkoxy, cyano, C1-4 alkylcarbonyloxy, aminocarbonyloxy, mono- or di-C1-4-alkylcarbonyloxy, -S (O) n-C1-6 alkyl, wherein n is 0, 1 or 2, triazolyl (for example 1,2,4-triazol-1-yl), trialkyl C1 - 4-silyloxy, optionally substituted phenoxy, optionally substituted thienyloxy, optionally substituted benzyloxy or optionally substituted thienylmethoxy, or R5 is optionally substituted phenyl, optionally substituted thienyl or optionally substituted benzyl, in which the optionally substituted phenyl and thienyl rings of the values of R5 are optionally substituted with one, two or three substituents that are selected from halo, hydroxy, mercapto, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 alkoxy, C2-4 alkenyloxy, C2 alkynyloxy 4, halo-C 1-4 alkyl, halo-C 1-4 alkoxy, C 1-4 alkylthio, ha lo-C 1-4 alkylthio, hydroxyC 1-4 alkyl, C 1-4 alkoxyC 1-4 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkylC 1-4 alkyl, phenoxy, benzyloxy, cyano, isocyano, thiocyanate, isothiocyanate , nitro, -NR m R n, -NHCOR m, -NHCONR m R n, -CONR m R n, -SO2R m, OSO2R m, -COR m, -CR n = NR m or -N = CR m R n, wherein R m, R n are independently hydrogen, C1-4 alkyl, halo C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C3-6 cycloalkyl, C3-6 cycloalkyl C1-4 alkyl, where the phenyl and benzyl groups optionally substituted with halogen, C1-4 alkyl-C1-4 alkoxy.