首页>
外国专利>
Regulation of cardiac contractility and heart failure propensity
Regulation of cardiac contractility and heart failure propensity
展开▼
机译:心脏收缩力和心力衰竭倾向的调节
展开▼
页面导航
摘要
著录项
相似文献
摘要
The methods and compositions of the present invention find use in altering expression of PKCα in transgenic animals. The compositions of the invention include isolated transgenic animal cells, transgenic tissue, transgenic animals, and transgenic mice. The transgenic animals of the invention exhibit altered PKCα activity. The methods allow generation of transgenic animals with altered expression of PKCα. The invention allows modulation of cardiac contractility. In particular, the invention provides a method for altering the susceptibility of a transgenic animal to cardiomyopathy. A transgenic animal of the invention finds use in identifying anti-cardiomyopathic compounds.
展开▼