IDENTIFICATION OF IMMUNOLOGICALLY EFFECTIVE EPITOPES ON THE SURFACE OF RED BLOOD CELLS AND THEIR USE IN A METHOD OF INDUCING TOLERANCE THERETO

摘要

The present invention relates to a method of identifying an immunologically effective epitope, the method comprising: a) preparing an oligomer of a protein present on the surface of a red blood cell which includes a polymorphism therein and b) ascertaining whether the oligomer stimulates T-cells and a composition comprising an immunologically effective epitope for the tolerisation of a subject that has been exposed to an antithetical allele.