首页> 外国专利> APPLICATION OF (HALOBENZYLOXY) BENZYLAMINO-PROPANAMIDES FOR THE PRODUCTION OF MEDICINES, ACTING AS SELECTIVE MODULATORS OF SODIUM AND / OR CALCIUM CHANNELS

APPLICATION OF (HALOBENZYLOXY) BENZYLAMINO-PROPANAMIDES FOR THE PRODUCTION OF MEDICINES, ACTING AS SELECTIVE MODULATORS OF SODIUM AND / OR CALCIUM CHANNELS

机译:(卤代苯甲酰)苯甲酰胺-丙酰胺在生产药物中的应用,用作钠和/或钙通道的选择性调节剂

摘要

1. Use of (R) -2- [4- (2-fluorobenzyloxy) benzylamino] propanamide and (R) -2- [4- (2-chlorobenzyloxy) benzylamino] -N-methylpropanamide as single isomers or pharmaceutically acceptable salts thereof for the production of a drug that selectively acts as a modulator of sodium and / or calcium channels, for the prevention, relief and / or treatment of pathological processes selected from pain, migraine, inflammatory processes that affect all body systems, disorders that affect the skin and adjacent tissues, disorders respiratory system dist properties of the immune and endocrine systems, gastrointestinal and genitourinary disorders, characterized in that the specified drug is mainly devoid of any effect of MAO inhibition or exhibits a significantly lower effect of MAO inhibition in dosages therapeutically effective in the prevention, relief and / or treatment of this pathological process. 2. The use according to claim 1, wherein the pathological process is selected from pain, migraine, inflammatory, genitourinary and gastrointestinal disorders. The use according to claim 2, in which the pathological process is a pain syndrome or migraine. The use according to claim 3, in which the pathological process is a pain syndrome. The use according to claim 4, in which the pain syndrome is either neuropathic or inflammatory type. The use of claim 4, wherein the pain syndrome is acute or chronic pain. The use according to claim 3, in which the pathological process is migraine. The use according to any one of claims 1 to 7 (R) -2- [4- (2-fluorobenzyloxy) benzylamino] propanamide as a single isomer or as a pharmaceutical
机译:1.(R)-2- [4-(2-氟苄氧基)苄氨基]丙酰胺和(R)-2- [4-(2-氯苄氧基)苄氨基] -N-甲基丙酰胺的单一异构体或其药学上可接受的盐的用途用于生产选择性充当钠和/或钙通道调节剂的药物,用于预防,缓解和/或治疗选自疼痛,偏头痛,影响全身系统的炎性过程,影响疾病的疾病的病理过程皮肤和邻近组织,疾病免疫系统和内分泌系统的呼吸道系统特性,胃肠道和泌尿生殖系统疾病,其特征在于所指定的药物在治疗有效剂量时主要没有MAO抑制作用或表现出明显较低的MAO抑制作用在预防,缓解和/或治疗这种病理过程中。 2.根据权利要求1的用途,其中所述病理过程选自疼痛,偏头痛,炎性,泌尿生殖系统和胃肠道疾病。 3.根据权利要求2的用途,其中所述病理过程是疼痛综合征或偏头痛。 4.根据权利要求3的用途,其中所述病理过程是疼痛综合征。 5.根据权利要求4的用途,其中所述疼痛综合征是神经性或炎性类型。 5.根据权利要求4所述的用途,其中所述疼痛综合征是急性或慢性疼痛。 4.根据权利要求3的用途,其中所述病理过程是偏头痛。 8.根据权利要求1至7中任一项的用途,(R)-2- [4-(2-氟苄氧基)苄氨基]丙酰胺为单一异构体或作为药物

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