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APPLICATION OF (HALOBENZYLOXY) BENZYLAMINO-PROPANAMIDES FOR THE PRODUCTION OF MEDICINES, ACTING AS SELECTIVE MODULATORS OF SODIUM AND / OR CALCIUM CHANNELS
APPLICATION OF (HALOBENZYLOXY) BENZYLAMINO-PROPANAMIDES FOR THE PRODUCTION OF MEDICINES, ACTING AS SELECTIVE MODULATORS OF SODIUM AND / OR CALCIUM CHANNELS
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机译:(卤代苯甲酰)苯甲酰胺-丙酰胺在生产药物中的应用,用作钠和/或钙通道的选择性调节剂
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摘要
1. Use of (R) -2- [4- (2-fluorobenzyloxy) benzylamino] propanamide and (R) -2- [4- (2-chlorobenzyloxy) benzylamino] -N-methylpropanamide as single isomers or pharmaceutically acceptable salts thereof for the production of a drug that selectively acts as a modulator of sodium and / or calcium channels, for the prevention, relief and / or treatment of pathological processes selected from pain, migraine, inflammatory processes that affect all body systems, disorders that affect the skin and adjacent tissues, disorders respiratory system dist properties of the immune and endocrine systems, gastrointestinal and genitourinary disorders, characterized in that the specified drug is mainly devoid of any effect of MAO inhibition or exhibits a significantly lower effect of MAO inhibition in dosages therapeutically effective in the prevention, relief and / or treatment of this pathological process. 2. The use according to claim 1, wherein the pathological process is selected from pain, migraine, inflammatory, genitourinary and gastrointestinal disorders. The use according to claim 2, in which the pathological process is a pain syndrome or migraine. The use according to claim 3, in which the pathological process is a pain syndrome. The use according to claim 4, in which the pain syndrome is either neuropathic or inflammatory type. The use of claim 4, wherein the pain syndrome is acute or chronic pain. The use according to claim 3, in which the pathological process is migraine. The use according to any one of claims 1 to 7 (R) -2- [4- (2-fluorobenzyloxy) benzylamino] propanamide as a single isomer or as a pharmaceutical
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