USE OF SODIUM CHANNEL BLOCKERS AND ASPIRIN FOR THE MANUFACTURE OF MEDICAMENTS FOR PRODUCING SYNERGISTIC ANALGETIC EFFECT IN MAMMALS

摘要

The use of a sodium channel blocker which binds to an alpha -subunit of the SS1 or SS2 site and aspirin as an analgesic is claimed. ACTIVITY : Analgesic. In the acetic acid writhing test, administration of tetrodotoxin at 0.79 Microg/kg, aspirin at 25.0 mg/kg or tetrodotoxin at 0.79 Microg/kg and aspirin at 25.0 mg/kg reduced writhing by 40.6%, 35.6% and 81.6% respectively. MECHANISM OF ACTION : Sodium-Antagonist.