In the conscious obstacle patient, the kit for detection of sick condition which includes the method of detection of the sick condition which the quantity of the huonvuiruburando factor analyzes nicking enzyme and/or activity, in the conscious obstacle patient, and the antibody or the fragment, or huonvuiruburando factor or that fragment which are connected to the huonvuiruburando factor nicking enzyme uniquely in the conscious obstacle patient is disclosed. In detection of the sick condition, for example, detection of brain blood vessel obstacle and detection of artery hardenable blood vessel obstacle, or, heavily seriously detection of degree or estimate of degree is included heavily seriously.
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