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SCREENING ASSAY TO IDENTIFY MODULATORS OF THE SLEEP/WAKE CYCLE
SCREENING ASSAY TO IDENTIFY MODULATORS OF THE SLEEP/WAKE CYCLE
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机译:筛选检查以识别睡眠/唤醒周期的调制器
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摘要
Screening assays for identifying agents that modulate BK channel activity and further modulate the sleep/wake cycle in a subject, circadian regulated locomotor activity in a subject, or both are provided, as are agents identified using such screening assays. Also provided are methods of modulating the sleep/wake cycle in a subject and methods of modulating circadian regulated locomotor activity in a subject by administering an agent that modulates BK channel activity to the subject, for example, an agent identified by a screening assay as disclosed.
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