COMBINED PHARMACEUTICAL FORMULATION WITH CONTROLLED-RELEASE COMPRISING DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS AND HMG-COA REDUCTASE INHIBITORS.

摘要

The present invention relates to a chronotherapeutic combination pharmaceutical formulation, which is designed to control the release of each ingredient of the combined drug in a predetermined rate based on the principle of the so-called chronotherapy, where drugs are administered to exhibit pharmacological activities at predetermined time intervals. The formulation of the present invention comprises a dihydropyridine, calcium channel blocker that affects cytochrome P450 enzyme, and a statin, lipid-lowering agent, as active ingredients. Further, it is prepared in such a manner that the respective release rate of the above ingredients can be controlled, thereby preventing antagonistic effects and side effects resulting from the interaction of the above ingredients, while maintaining the synergistic effect, and providing easy medication.