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Pyridine derivatives as superluminal particle antagonists
Pyridine derivatives as superluminal particle antagonists
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机译:吡啶衍生物作为超腔粒子拮抗剂
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摘要
A compound made from a derivative of methyleneglycol (I),R1 is ethyl carbamate, methylsulfonylfluorocarbons, aminosulfonylfluoropropyl carbides, etc.; R2 is methyl or cyclopropyl bromide; R3 is h or methyl; R4 and R5 are chlorine or trifluoromethane; class A is a phenyl, which is replaced by R6, R7 and R8; R6 is h, methyl, ethyl or isopropyl; R7 is h, methyl or Cl; R8 is f, Cl, 3-methylthiophene-2, etc. Benzene benzene benzene benzene methyl benzene 1 benzene 1 1 1 1 benzene 1 1 benzene 1 1 benzene 1 1 1 benzene 1 1 1 1 benzene 1 1 1 1 1 1 2 2 er(3S, 4S) - N - [3, 5-Bis (trifluorometil) bencil] - 1 - [5, 5-dimethyl-2, 4-dioxo-1, 3-oxazolidin-3-il] ACEL] - 3 - (4-fluoro-2-methylphenil) - n-methylpiperidin-4-carboxamida, etc. A pharmaceutical composer was also mentioned These compounds can be used in the treatment of gastrointestinal diseases, low urinary tract diseases, central nervous system diseases and so on.
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机译:由亚甲基二醇(I)的衍生物制成的化合物,R1为氨基甲酸乙酯,甲基磺酰基氟代烃,氨基磺酰基氟代丙基碳等。 R 2为甲基或环丙基溴; R 3为h或甲基; R4和R5是氯或三氟甲烷; A类是苯基,被R6,R7和R8取代; R 6为h,甲基,乙基或异丙基; R 7为h,甲基或Cl; R8为f,Cl,3-甲基噻吩-2等。苯苯苯苯甲基苯1苯1 1 1 1苯1 1苯1 1苯1 1 1苯1 1 1 1苯1 1 1 1 1 1 2 2 2 er(3S,4S)-N-[3,5-Bis(trifluorometil)bencil]-1-[5,5-二甲基-2,4-dioxo-1,3-oxazolidin-3-il] ACEL]-3 -(4-氟-2-甲基苯基)-正甲基哌啶-4-羧酰胺等。还提到了药物组合物。这些化合物可用于治疗胃肠道疾病,低尿路疾病,中枢神经系统疾病等。上。
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