BENZAZOLES REPLACED AND USE OF THE SAME AS INHIBITORS OF THE QUINASA RAF.

摘要

A compound of formula (I): ** see formula ** in which, X1 and X3 are independently selected from N, -NR4-, -O- or -S-, in which R4 is hydrogen or lower alkyl, with the condition that at least one of X1 and X3 must be N or -NR4-; X2 is -NH- or - (CH2) m-, where m is 0, 1, 2, 3 or 4; A1 is substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, polycyclic aryl, polycyclic arylalkyl, heteroaryl, biaryl, heteroarylaryl, or heteroarylheteroaryl; R1 is hydrogen or substituted or unsubstituted lower alkyl, alkoxyalkyl, lower alkyloxy, amino, aminoalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyloxyalkylheterocycloalkyl, heteroarylalkyl, lower cycloalkyl alkyl, heterocycloalkylalkyl, lower alkylheterocycloalkyl, lower alkylcycloalkyl, lower alkylcycloalkyl, alkyl or lower heteroarylalkyl; R2 is hydrogen or lower alkyl; each R3 and R3 '' is independently selected from hydrogen, halogen, hydroxy, cyano, lower alkyl, or lower alkoxy; and p and q are independently 0, 1, 2 or 3; or a pharmaceutically acceptable salt or ester; and wherein, lower alkyl includes straight or branched chain, substituted or unsubstituted alkyl groups having 1-6 carbon atoms; and lower alkoxy refers to RO- in which R is a lower alkyl.