NEGATIVE GENETIC REGULATION OF CANCER CELL RENEWAL IN SYNERGY WITH NOTCH- OR NUMB-SPECIFIC IMMUNOTHERAPY

摘要

We disclose a method of treating a cancer in a patient by immunizing the patient against a peptide derived from a protein selected from the group consisting of Notch 1, Notch2, Notch3, and Notch4. We further disclose a composition containing a peptide as described above and a pharmaceutically-acceptable carrier. In addition, we disclose a method of treating a cancer in a patient by immunizing the patient against a peptide derived from a protein selected from the group consisting of Numbl, Numb2, Numb3, and Numb4. We also disclose a composition containing a peptide as described above and a pharmaceutically- acceptable carrier. Further, we disclose a method of treating a cancer in a patient by administering to the patient a composition comprising an antibody against a peptide derived from a protein selected from the group consisting of Notch 1, Notch2, Notch3, Notch4, Numbl, Numb2, Numb3, and Numb4.