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REGULATION OF MYELINATION BY NECTIN-LIKE (NECL) MOLECULES
REGULATION OF MYELINATION BY NECTIN-LIKE (NECL) MOLECULES
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机译:类似于Nectin(NECL)分子的髓鞘调节
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摘要
The invention provides polypeptides comprising isolated domains of Necl proteins, particularly of Necl4, that mediate axon-glia adhesion required for myelination. The invention further provides pharmaceutical compositions comprising as the active ingredient a polypeptide comprising an isolated Necl4 domain, or a polynucleotide encoding a polypeptide comprising an isolated Necl4 domain. Further provided are antibodies directed against isolated Necl domains, siRNA capable of down regulating Necl4 expression, and methods for treating neurological disorders which are associated with aberrant myelination.
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