Methods and systems are disclosed for treating dry eye or a dry eye symptom with at least one formulation having at least one metal-containing catalytic antioxidant that provides enhanced benefits as compared to currently available treatments, including at least enhanced tissue regeneration. Various treatment approaches of embodiments of the present invention reduce damage to ocular gland tissue and/or allow preservation of gland function. In various embodiments, the intervention approach leads to a reduction of oxidative stress, reduction the cellular degeneration, and/or decline in the death of acinar cells induced by oxidative stress as compared to the prior art treatments. Various embodiments are suitable for the treatment of congenital, autoimmune conditions, chemical damage, mechanical damage, infections, and/or the like.
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