NOVEL 2,4,5-TRISUBTITUTED-1,3-THIAZOLE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARATION, THERAPEUTIC AGENT FOR INFLAMMATORY DISEASE INDUCED BY SPC ACTIVITY CONTAINING 2,4,5- TRISUBSTITUTED-1,3-THIAZOLE DERIVATIVES AS AN EFFECTIVE INGREDIENT

摘要

Provided are a 2,4,5-trisubstiuted-l,3-thiazole derivative represented by the following Chemical Formula 1, a pharmaceutically acceptable salt thereof, a method for preparation thereof, and a use thereof as an effective ingredient in a therapeutic agent for inflammatory disease induced by sphingosylphosphorylcholine (SPC). The 2,4,5-trisubstiuted-l,3-thiazole derivative of the present invention has been confirmed to have superior inhibition activity against SPC receptor in an animal experiment using human-derived endothelial cells and mice. Thus, a pharmaceutical composition for treating inflammatory disease containing the 2,4,5-trisubstiuted-l,3-thiazole derivative or a pharmaceutically acceptable salt thereof as an effective ingredient may be useful for treating inflammation, itching or skin infection associated with atopic dermatitis or other disease induced by SPC receptor.