An orthotopic artificial bladder endoprosthesis (100) is disclosed, comprising an enclosure or bag or balloon made from a multi-layer membrane (1) comprising an intermediate base layer (2) made of a soft, elastic, synthetic material able to guarantee a correct deformation of the prosthesis, an inner coating layer (4) of highly biocompastible biomaterial able not to deteriorate upon contact with the urine and an outer coating layer (5) of highly biocompatible biomaterial able to prevent the fusing with the patient's internal tissue. The endoprosthesis further comprises a catheter or stent (80) connected to said prosthesis and adapted to be inserted into a channel formed in the patient's lumbar region to allow the outflow of the urine from the inside of the prosthesis, through the stent, out of one of the patient's flanks.
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