SIGNAL PEPTIDE TARGETING TO LIPID DROPLET AND METHOD FOR TARGETING HETEROLOGOUS PROTEIN TO LIPID DROPLET USING THE SAME

摘要

A signal peptide targeting to lipid droplet for targeting a heterologous protein to lipid droplet is provided to cure and prevent lipid droplet-related diseases containing obesity, diabetes and arteriosclerosis. An expression vector comprises a gene coding signal peptide of SEQ ID NO:1 and a gene coding heterologous protein. The heterologous protein is the lipase or protein kinase A(PKA). The composition for targeting a heterologous protein to lipid droplet comprises the expression vector.