METHOD FOR MODIFICATION OF FOOD BEHAVIOR AND APPLICATION OF PYY OR ITS AGONIST AS A MEANS FOR MODIFICATION OF FOOD BEHAVIOR

摘要

1。 Ways to reduce calorie intakeReduce food consumption,Or loss of appetite,Or the main body of increased energy consumption,differWhat is an external introduction to the number of PYY entities,(a) The physiological level of PYY3-36 was determined after food intake;Or peripheral introduction of PYY receptors,(a) After food intake, the calorie intake decreased;Food consumption or reduce appetite, thereby increasing the energy consumption of the main body.;2。 The P.1 of this method is different from that of the main body with redundant mass.;3。 According to п. 1, the method is different from that of the subject suffering from obesity.;4。 The method is different from 1.;5。 In a different way from2. PYY or PYY receptor external including oral administration,subcutaneousintravenous injectionIntramuscular,Intermittently,groinInternal circulation,In the vagina,Intraperitoneal,localHypermucusBeechRectum, rectumOr injected lung components.;6。 Type 5 method, the difference is that the dosage of PYY or its sedative is about 45 to 135 mg / kg of body weight.;7。 Type 6 method, the difference is that the dosage of PYY or its sedative is about 72 mg / kg body weight.;8。 One method of P.1, unlike PYY or its agonist, inputs food at least 30 minutes ago.;9。 The first method, which is different from PYY or the surrounding of its radicals, has a t value of about 0 At least 30 minutes before eating, the body weight changes from about 135 mg / kg / kg / kg.;10。 In a different way from2. The main body should also input the quantity of additional agent effectively in the treatment,appetite suppressant Who introduced amfepramon)（FinnishMasindor,PhenylpropanolamineAmphetamineDexfenfluramin or fluorocarbons.;11。 One method of P.1, unlike PYY or its sedative input, effectively reduces their calorie intake by at least 2 hours.;12。 The type 11 method, unlike PYY or the number of its ballast input objects, effectively reduces their calorie intake by about 2 to 24 hours.;13。 Method 1, different from the way of subject and person.;14。 A method of P.1, unlike a PYY promoter, contains a molecule in which there is a specific Cy2 receptor.;15。 The method of P. 14, with PYY accelerator, added a part of c-fos in the arc drama in contact with PYY accelerator.;16。 One method of P.1, which differs from a specific PYY promoter called neurons, contains neuropeptide Y and inhibits neuronal activity, which contains neuropeptide Y.;17。 P. The difference between the two methods is that PYY promoter reduces the frequency of repetitive action potential pulses of neurons containing neuropeptide Y.;18。 The method of p.16, which is different from that of neurons containing neuropeptide Y, synapses of shengzan and precursor pigment hormone neurons, including a PYY promoter and neurons, The substance containing neuropeptide Y can increase the activity of protoopioid platelet neurons.;19。 Method 18, different fromWhat is pain PYY, called neurons,Equipment containing neuropeptide Y reduces the repetition rate of action potential pulses of neurons,a. The substance containing neuropeptide Y decreased the activity of neurons;The potential of neuropeptide Y-containing neurons increased.;20。 According to the π. 1 method, it is different from the method of reducing the main body's appetite.;21。 The 20th method, different from the main body of food consumption reduction.;22。 Method 21, which is different from reducing the body's calorie intake.;23。 Method 1 is different from preventing or reducing the accumulation of the main body.;24。 The first method is different from the method of inducing or maintaining the mass loss of the main body.;25。 Type 1 methods, unlike PYY or its receptor T input, range from about 0.5 to about 135 mg / kg of body weight.;26。 The first method is different from the method of inducing or enhancing saturation and saturation sensation.;27。 Method 1, different from hunger in the subject and the feeling of hunger.;28。 The first method, which is different from PYY or its receptor, can be used multiple times or separately.;29。 The first method is different from peripheral injection of PYY or its sedative in pulse dose.;30。 In a different way from1. The form of peripheral introduction of PYY or its receptor theorists;Guaranteed decelerationLong term or controlled release of drugs,Or with a pump,Or the drug introduction of the implant.;31。 The first method is different from the introduction of PYY or its promoter around the dose range of about 5 nm to about 50 nm.;32。 The first type of method, the dose of PYY or its sedative is about 2 nm to 20 nm.;33。 Class 31 method, which is characterized in that the dosage of PYY or its sedative is about 10 nm.;34。 One method of P.1, which differs from an object of input, is the amount of additional drugs that are effective in the treatment of anorexia.;35。 The method of p. 1, different from an additional infusion of t at least one dose to reduce plasma glucose levels, agent, Change the lipid content in plasma or reduce food intake.;36。 The first method, which is different from an entity, can maintain the ideal body mass or maintain the ideal body mass index.;37。 The first method is to regard the breach of contract that may lead to obesity or overweight as defective or dangerous.;38。 A method of P.1, unlike a subject suffering from a violation, is due to a complex or deteriorating IMS at St. Z, with relatively high nutritional levels.;39。 The P.1 of this method is different from the main input t agost PYY.;40。 P. The physiological level of py3-36 was 40-60 MPa, which was different from that of dietary.;41。 P. The physiological level of py3-36 was 40-50 ppm.;42。 Use PYY or its promoter as DD to reduce calorie intake, reduce food intake, or reduce appetite, or increase the body's energy consumption.;43。 PYY or its promoter is used as an active ingredient in the production of DD drugs to reduce calorie intake and food consumption, Or reduce appetite, or increase the energy consumption of the main body.