METHOD FOR PRODUCING NEW THIOTROPY SALTS, NEW THIOTROPY SALTS AS SUCH AS AND PHARMACEUTICAL COMPOSITIONS

摘要

1. The method of obtaining new salts of tiotropium formula 1! ! where! X- means anion other than HCO3 - (bicarbonate), consisting in the fact that bicarbonate is tiotropium of formula 2! ! in a suitable solvent, reacts with acid HX, where X is as defined above. ! 2. The method according to claim 1, where! X- is a halide, HSO4 -, H2PO4 - or the anion is selected from the group consisting of optionally substituted alkyl sulfonate, optionally substituted alkenyl sulfonate, optionally substituted cycloalkyl sulfonate, optionally substituted alkyl sulfate, optionally substituted alkenyl sulfate, optionally substituted alkenyl sulfate, substituted aryl sulfonate, optionally substituted aryl sulfate, optionally substituted heterocyclic sulfonate and optionally substituted geterotsiklilsulfat,! or ! X- is R-COO-, where R is hydrogen, COOH, COO- (C1-C6) alkyl or a group selected from the group consisting of optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted aryl and optionally substituted heterocyclyl. ! 3. The method according to claim 1 or 2, where! X- is a halide, HSO4 -, H2PO4 - or an anion selected from the group consisting of optionally substituted C1-C10 alkyl sulfonate, optionally substituted C2-C10 alkenyl sulfonate, optionally substituted C2-C10 alkynyl sulfonate, optionally substituted C3-C8 cycloalkyl sulfonate, optionally C2-C10 alkenyl sulfate optionally substituted with C2-C10 alkini