INTRODUCTION TO THE RESPIRATORY WAYS OF AN ACTIVATED PROTEIN C IN INFLAMMATORY CONDITIONS AFFECTING THE RESPIRATORY WAY

摘要

1. A method of treating or preventing extravascular deposition of fibrin in the respiratory tract in humans, in particular in the alveolar or bronchoalveolar spaces, comprising administering to the person an activated protein C or its biologically active derivative through the respiratory tract through intratracheal, intrabronchial or intraalveolar administration. ! 2. The method according to claim 1, in which the deposition of fibrin is caused by inflammatory disease of the lungs. ! 3. The method according to claim 2, in which the inflammatory lung disease is selected from the group consisting of: ALI, ARDS, pneumonia, acute bronchoalveolar diseases, chronic bronchoalveolar diseases, fibrosing alveolitis or bronchial asthma. ! 4. The method according to any one of the preceding paragraphs, wherein the inflammatory lung disease refers to a condition selected from the group consisting of: direct or indirect lung injury, pancreatitis, aspiration pneumonitis, sepsis, severe sepsis and / or septic shock, and / or caused drug of acute pulmonary failure. ! 5. The method according to any one of the preceding paragraphs, in which the activated protein C is administered by bronchoalveolar lavage with a solution of activated protein C.! 6. The method according to any one of the preceding paragraphs, wherein the activated protein C is administered by blindly washing the trachea with a solution of activated protein C.! 7. The method according to any one of the preceding paragraphs, in which the activated protein C is administered by inhalation with a nebulized solution of activated protein C.! 8. The method according to any one of the preceding paragraphs, in which the activated protein C is administered in the middle