SYNTHESIS OF ESTERS OF 2-CHLOROMETHYL-6-METHYLBENZOIC ACID

摘要

FIELD: chemistry.;SUBSTANCE: present invention pertains to new compounds with formula , in which R represents H, (C₁-C₁₂)-alkyl or (C₁-C₄)-alkyl-(C₆-C₁₂)-aryl. In the alkyl, one or more CH₂-groups can be substituted with -O-. The invention also relates to the method of obtaining these compounds. The method involves reacting dimethylbenzoic acid ester with formula where R assumes values given above, with a chlorinating agent in an inert solvent or without a solvent at temperature above 40C, and then cleaning, if necessary. Formula (I) compounds are essential intermediate products during synthesis of PPAR agonists with formula , in which R represents H, (C₁-C₁₂)-alkyl or (C₁-C₄)-alkyl-(C₆-C₁₂)-aryl. In the alkyl, one or more CH₂-groups can be substituted with -O-; Y represents -(CH₂)₃-, 1,3-phenylene, 1,3-cyclohexanediyl; R' represents H, F, Br, CF₃, (C₁-C₆)-alkyl, O-(C₁-C₆)-alkyl, phenyl; CF₃; obtained from reaction of compounds with formula with formula (I) compounds in toluene, N-methylpyrrolidone or other aprotic solvents, in the presence of a suitable base, at temperature lying in the -78C - +50C interval, with subsequent extractive processing and, if necessary, crystallisation of the end product.;EFFECT: obtaining new compounds.;8 cl, 5 ex