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New cyclic peptides having a random alternation of L-alpha-aminoacyl residues and aza-beta-3-aminoacyl residues, useful to treat infectious diseases e.g. nosocomial infections, tuberculosis and septicemia
New cyclic peptides having a random alternation of L-alpha-aminoacyl residues and aza-beta-3-aminoacyl residues, useful to treat infectious diseases e.g. nosocomial infections, tuberculosis and septicemia
Cyclic peptides having a random alternation of L-alpha -aminoacyl residues and aza-beta 3-aminoacyl residues (A), are new. Cyclic peptides having a random alternation of L-alpha -aminoacyl residues and aza-beta 3-aminoacyl residues of formula (-NH-N(R 1)-CH 2-C(=O)-) (A), are new. R 1lateral chain comprising proteogenic or non-proteogenic group. Provided that, two L-alpha -aminoacyl residues are separated by at least one aza-beta 3-aminoacyl residues and total number of L-alpha -aminoacyl residues and aza-beta 3-aminoacyl residues is 4-8. ACTIVITY : Antimicrobial; Antibacterial; Antiparasitic; Virucide; Fungicide; Antitubercular; Tuberculostatic; Immunosuppressive; Antiinflammatory; Respiratory-Gen. MECHANISM OF ACTION : None given.
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机译：具有L-α-氨基酰基残基和氮杂-β3>-氨基酰基残基（A）的随机交替的环肽是新的。具有式（-NH-N（R 1）-CH 2-C（= O）-）（A）的L-α-氨基酰基残基和aza-beta 3>-氨基酰基残基的随机交替的环肽是新的。 R 1侧链包含蛋白质或非蛋白质基团。假设两个L-α-氨基酰基残基被至少一个氮杂-β3>-氨基酰基残基隔开，并且L-α-氨基酰基残基和氮杂-β3>-氨基酰基残基的总数为4-8。活性：抗菌;抗菌;抗寄生虫;杀病毒剂;杀菌剂抗结核结核病;免疫抑制消炎（药;呼吸源。作用机理：未给出。
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