Inhibitors of GPIb-vWF interaction, their production and use

摘要

The present invention relates to compounds of the formula I, CHEM in which R1, R2, A, B, D, E, n, m or o have the meanings indicated below. ??The compounds of the formula I are valuable pharmacologically active compounds. They are reversible inhibitors of the interaction between the plasma protein von Willebrand factor (vWF) and the blood platelet receptor glycoprotein Ib-IX-V complex (GPIb). They exhibit an antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of athero-thrombotic diseases.