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System and Method of Chemical Imaging Using Pulsed Laser Excitation and Time-Gated Detection to Determine Tissue Margins During Surgery

机译:化学脉冲成像和时间门控检测在手术过程中组织边缘的化学成像系统和方法

摘要

System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed.
机译:使用脉冲激光激发和时间选通检测来区分生物样品中组织边缘的系统和方法。用基本上单色的脉冲激光照射包含生物组织的区域,从而产生拉曼散射光子。使用时间门控检测来检测拉曼散射光子,从而从包含生物组织的区域的赘生部分或非赘生部分的特征区域的照射区域中获得拉曼光谱图像。区分赘生部分和非赘生部分之间的边界,并显示拉曼光谱图像中的边界位置。

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