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Ovarian cancer cell and myeloma cell surface glycoproteins, antibodies thereto, and uses thereof
Ovarian cancer cell and myeloma cell surface glycoproteins, antibodies thereto, and uses thereof
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机译:卵巢癌细胞和骨髓瘤细胞表面糖蛋白,其抗体及其用途
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摘要
The present invention is directed to cell surface antigens found on myeloma cells and on ovarian cancer cells that are recognized by monoclonal antibodies, and antibody binding fragments thereof, as described. The monoclonal antibodies of the invention are capable of being used for therapeutic, screening, diagnostic and cell purification purposes. A representative and exemplified monoclonal antibody of the present invention recognizes and binds to an epitope common to a surface antigen that is expressed on multiple myeloma cells and to a surface antigen that is expressed on ovarian cancer cells. The function of this monoclonal antibody both in vivo and in vitro is demonstrated.
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