Use of a compound of quinilinil - 4 - phenyl - and Oxy - ciclopropildicarboxamida ErbB inhibitor for preparing Medicine useful for Treatment of cancers

摘要

Use of: (a) a compound of quinilinil Oxy - 4 - phenyl - ciclopropildicarboxamida of formula (1) or a pharmaceutically acceptable Salt thereof; and (b) a ErbB inhibitor that Inhibits ErbB receptor - 1 or erbb-2 and erbb-3 or a combination thereof; in which R1 is alkyl C1 - 6; R2 is alkyl C1 - 6 N - (CH2) or - N (R5) 2; R3 is cl or F; R4 or R5 is ci f; each is independently alkyl C1 - 6 orAlong with the nitrogen Atom to which they are United, form a Group piperidinilo or morpholino, pirazinilo; n is 2, 3 or 4, p is 0 OR 1; and q is 0, 1 or 2, to prepare a useful drug for the treatment of cancer in a patient.The use of a compound of formula (1) which is the compound of formula (1) or a pharmaceutically acceptable Salt thereof, for treating a patient suffering from breast cancer or cancer of the head and neck. Such uses or pharmaceutically acceptable Salt of the compound of formula (1); or the ErbB inhibitor; or a combination thereof with a pharmaceutically acceptable excipient.These uses are for a combination therapy is more effective than the Therapies described previously. Claim 1: the use of any of claims 1 to 3, wherein the ErbB inhibitor is trastuzumab. Claim 1: the use of any of claims 1 to 3, wherein the ErbB inhibitor is cetuximab.