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FUSED BICYCLE COMPOUND

机译:熔融自行车化合物

摘要

wherein the ring A is a benzene ring having a substituent R1, fused to an adjacent 6-membered heterocyclic ring and further optionally having a substituent(s) other than R1, R1 is an alkylsulfonylamino group etc., R2 and R3 are (a) the same of different and a hydrogen atom, an alkyl group or a substituted or unsubstituted aryl group, (b) combined each other to form an oxo group or (c) combined each other at its terminal together with the adjacent carbon atom to form a cycloalkyl group, X is a group of =N-, =C(R4)- or -CH(R4), R4 is (a) a hydrogen atom, (b) a cyano group, (c) a halogen atom, (d) an alkyl group, (e) an alkenyl group, (f) a cycloalkyl group (g) an alkanoyl group, (h) a carbamoyl group or (i) a cycloalkenyl group, Ar is an optionally substituted aromatic cyclic group and a dotted line means presence or absence of a double bond, or a pharmaceutically acceptable salt thereof, which is useful as an antihypertensive agent etc.
机译:其中环A是具有取代基R 1的苯环,其与相邻的6元杂环稠合并且还任选具有除R 1之外的取代基,R 1是烷基磺酰基氨基等,R 2和R 3是(a) (b)彼此结合形成氧代基团;或(c)在其末端与相邻的碳原子彼此结合而形成氢原子,烷基或取代或未取代的芳基;环烷基,X是= N-,= C(R4)-或-CH(R4)的基团,R4是(a)氢原子,(b)氰基,(c)卤素原子,(d )烷基,(e)烯基,(f)环烷基(g)链烷酰基,(h)氨基甲酰基或(i)环烯基,Ar是任选取代的芳族环状基团,并带有点线表示存在或不存在可用作抗高血压剂等的双键或其药学上可接受的盐。

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